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زیست شناسی::
مسیر پیام رسانی انسولین
These are the genes encoding (1) DNA repair enzymes, (2) proteins of the insulin signaling pathway, (3) proteins in the mTORCl signaling pathway (a cascade that regulates translation), and (4) chromatin remodeling enzymes.
The pathway that regulates both dauer larva formation and longevity has been identified as the insulin signaling pathway (Kimura et al. 1997; Guarente and Kenyon 2000; Gerisch et al. 2001; Pierce et al. 2001).
While severe loss-of-function alleles in the insulin signaling pathway cause the formation of dauer larvae in any environment, weak mutations in the pathway enable the animals to reach adulthood and live four times longer than wild-type animals.
Downregulation of the insulin signaling pathway has several other functions.
Mice with loss-of-function mutations of the insulin signaling pathway live longer than their wild-type littermates (see Partridge and Gems 2002; Bliiher et al. 2003; Kurosu et ai. 2005).
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